Volume 32, Issue 4, Pages 216-223 (October 2009)

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ABSTRACT

ABSTRACT + REFS

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Leptin Levels in Thyroid Cancer

Accepted 5 September 2009.

Background

Leptin has physiological roles in multiple systems, and has possible effects on several carcinogenesis steps. The aim of this study was to investigate the leptin levels in thyroid papillary carcinoma (TPC) patients.

Methods

Forty-three female TPC patients and 30 healthy female control subjects were recruited for the study. TPC was diagnosed by fine needle aspiration biopsy. TPC patients had a bilateral total thyroidectomy operation and their leptin levels were measured before and 20 days after the operation.

Results

Serum leptin levels of TPC patients were higher than in control group subjects (21.15 ± 14.12 ng/mL vs. 9.89 ± 0.21 ng/mL, p < 0.05). The leptin levels decreased after total thyroidectomy (13.92 ± 10.55 ng/mL) compared to prethyroidectomy levels (22.94 ± 14.67 ng/mL) in 34 patients who came to the follow-up visit (p < 0.05). However, the decreased post-thyroidectomy levels of leptin were still statistically significantly higher than the control group levels. Multivariate regression analysis showed that the leptin levels in TPC patients were not related to age, menopausal status or pathologic occult status but were directly related to the cancer group.

Conclusion

Leptin levels were elevated in thyroid cancer, decreased after total thyroidectomy, and might be associated with thyroid papillary carcinogenesis.

Key Words: body mass index , leptin , thyroid papillary carcinoma

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References

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a Department of General Surgery, Ankara Diskapi Education and Research Hospital, Ankara, Turkey

b Department of Biochemistry, Celal Bayar University, Manisa, Turkey

c Department of General Surgery, Ankara Oncology Hospital, Ankara, Turkey

d Department of Biochemistry and Clinical Biochemistry, School of Medicine, Celal Bayar University, Manisa, Turkey

Address correspondence and reprint requests to Dr Melih Akinci, 44 Cadde 457, Sokak Lale Apt. No. 4/14, 06520 Cukurambar, Ankara, Turkey

PII: S1015-9584(09)60397-3

doi:10.1016/S1015-9584(09)60397-3

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