Asian Journal of Surgery
Volume 32, Issue 4 , Pages 216-223, October 2009

Leptin Levels in Thyroid Cancer

  • Melih Akinci

      Affiliations

    • Department of General Surgery, Ankara Diskapi Education and Research Hospital, Ankara, Turkey
    • Corresponding Author InformationAddress correspondence and reprint requests to Dr Melih Akinci, 44 Cadde 457, Sokak Lale Apt. No. 4/14, 06520 Cukurambar, Ankara, Turkey
    • ,
  • Funda Kosova

      Affiliations

    • Department of Biochemistry, Celal Bayar University, Manisa, Turkey
    • ,
  • Bahadir Cetin

      Affiliations

    • Department of General Surgery, Ankara Oncology Hospital, Ankara, Turkey
    • ,
  • Sabahattin Aslan

      Affiliations

    • Department of General Surgery, Ankara Oncology Hospital, Ankara, Turkey
    • ,
  • Zeki Ari

      Affiliations

    • Department of Biochemistry and Clinical Biochemistry, School of Medicine, Celal Bayar University, Manisa, Turkey
    • ,
  • Abdullah Cetin

      Affiliations

    • Department of General Surgery, Ankara Oncology Hospital, Ankara, Turkey

Accepted 5 September 2009.

Article Outline

Background

Leptin has physiological roles in multiple systems, and has possible effects on several carcinogenesis steps. The aim of this study was to investigate the leptin levels in thyroid papillary carcinoma (TPC) patients.

Methods

Forty-three female TPC patients and 30 healthy female control subjects were recruited for the study. TPC was diagnosed by fine needle aspiration biopsy. TPC patients had a bilateral total thyroidectomy operation and their leptin levels were measured before and 20 days after the operation.

Results

Serum leptin levels of TPC patients were higher than in control group subjects (21.15 ± 14.12 ng/mL vs. 9.89 ± 0.21 ng/mL, p < 0.05). The leptin levels decreased after total thyroidectomy (13.92 ± 10.55 ng/mL) compared to prethyroidectomy levels (22.94 ± 14.67 ng/mL) in 34 patients who came to the follow-up visit (p < 0.05). However, the decreased post-thyroidectomy levels of leptin were still statistically significantly higher than the control group levels. Multivariate regression analysis showed that the leptin levels in TPC patients were not related to age, menopausal status or pathologic occult status but were directly related to the cancer group.

Conclusion

Leptin levels were elevated in thyroid cancer, decreased after total thyroidectomy, and might be associated with thyroid papillary carcinogenesis.

Key Words:  body mass index , leptin , thyroid papillary carcinoma

No full text is available. To read the body of this article, please view the PDF online.

 

Back to Article Outline

References 

  1. Hedley AA , Ogden CL , Johnson CL , et al.   Prevalence of over-weight and obesity among US children, adolescents and adults, 1999–2002 . JAMA . 2004;291:2847–2850
  2. Zhang Y , Proenca R , Maffei M , et al.   Positional cloning of the mouse obese gene and its human homologue . Nature . 1994;372:425–432
  3. Tartaglia LA , Dembski M , Weng X , et al.   Identification and expression cloning of a leptin receptor, OB-R . Cell . 1995;83:1263–1271
  4. Schwartz MW , Seeley RJ , Campfield LA , et al.   Identification of leptin action in rat hypothalamus . J Clin Invest . 1996;98:1101–1106
  5. Wauters M , Considine RV , Van Gaal LF . Human leptin: from an adipocyte hormone to an endocrine mediator . Eur J Endocrinol . 2000;143:293–311
  6. Hardie L , Guilhot N , Trayhurn P . Regulation of leptin production in cultured mature white adipocytes . Hormone Metab Res . 1996;28:685–689
  7. Klein S , Wadden T , Sugerman HJ . AGA technical review on obesity . Gastroenterology . 2002;123:882–932
  8. Vona-Davis L , Rose DP . Adipokines as endocrine, paracrine, and autocrine factors in breast cancer risk and progression . Endocr Relat Cancer . 2007;14:189–206
  9. Deo DD , Rao AP , Bose SS , et al.   Differential effects of leptin on the invasive potential of androgen-dependent and -independent prostate carcinoma cells . J Biomed Biotechnol . 2008;2008:163902
  10. Macciò A , Madeddu C , Massa D , et al.   Interleukin-6 and leptin as markers of energy metabolic changes in advanced ovarian cancer patients . J Cell Mol Med . 2008 Jun 27; [Epub ahead of print]
  11. Jaffe T , Schwartz B . Leptin promotes motility and invasiveness in human colon cancer cells by activating multiple signal-transduction pathways . Int J Cancer . 2008;123:2543–2556
  12. Li L , Gao Y , Zhang LL , et al.   Concomitant activation of the JAK/STAT3 and ERK1/2 signaling is involved in leptin-mediated proliferation of renal cell carcinoma Caki-2 cells . Cancer Biol Ther . 2008;7; [Epub ahead of print]
  13. Carino C , Olawaiye AB , Cherfils S , et al.   Leptin regulation of proangiogenic molecules in benign and cancerous endometrial cells . Int J Cancer . 2008;123:2782–2790
  14. Gogas H , Trakatelli M , Dessypris N , et al.   Melanoma risk in association with serum leptin levels and lifestyle parameters: a case-control study . Ann Oncol . 2008;19:384–389
  15. Ribeiro R , Araújo A , Lopes C , et al.   Immunoinflammatory mechanisms in lung cancer development: is leptin a mediator? . J Thorac Oncol . 2007;2:105–108
  16. Lal G , Clark OH . Thyroid, parathyroid and adrenal . In:  Brunicardi FC ,  Andersen DK ,  Billiar TR , et al. editor. Shwartz's Principles of Surgery . New York: McGraw-Hill; 2005;p. 1395–1470
  17. Schauer PR , Schirmer BD . The surgical management of obesity . In:  Brunicardi FC ,  Andersen DK ,  Billiar TR , et al. editor. Shwartz's Principles of Surgery . New York: McGraw-Hill; 2005;p. 997–1016
  18. Jin L , Burguera BG , Couce ME , et al.   Leptin and leptin receptor expression in normal and neoplastic human pituitary: evidence of a regulatory role for leptin on pituitary cell proliferation . J Clin Endocrinol Metab . 1999;84:2903–2911
  19. Ahima RS , Prabakaran D , Mantzoros C , et al.   Role of leptin in the neuroendocrine response to fasting . Nature . 1996;382:250–252
  20. Legradi G , Emerson C , Ahima R , et al.   Leptin prevents fasting-induced suppression of prothyrotropin-releasing hormone messenger ribonucleic acid in neurons of the hypothalamic paraventricular nucleus . Endocrinology . 1997;138:2569–2576
  21. Fain J , Coronel E , Beauchamp M , et al.   Expression of leptin and beta 3-adrenergic receptors in rat adipose tissue in altered thyroid states . Biochem J . 1997;322:145–150
  22. Escobar-Morreale HF , Escobar del Rey F , Morreale de Escobar G . Thyroid hormones influence serum leptin concentrations in the rat . Endocrinology . 1997;138:4485–4488
  23. Seven R . Thyroid status and leptin in Basedow-Graves and multinodular goitre patients . J Toxicol Environ Health A . 2001;63:575–581
  24. Mazziotti G , Parkes AB , Lage M , et al.   High leptin levels in women developing postpartum thyroiditis . Clin Endocrinol . 2004;60:208–213
  25. Janeckova R . The role of leptin in human physiology and patho-physiology . Physiol Res . 2001;50:443–459
  26. Valcavı R , Zını M , Peino R , et al.   Influence of thyroid status on serum immunoreactive leptin levels . J Clin Endocrinol Metab . 1997;82:1632–1634
  27. Pınkne JH , Goodrick SJ , Katz J , et al.   Leptin and the pituitary-thyroid axis: a comparative study in lean, obese, hypothyroid and hyperthyroid subjects . Clin Endocrinol . 1998;49:583–588
  28. Dıekman MJ , Romijn JA , Endert E , et al.   Thyroid hormones modulate serum leptin levels: observations in thyrotoxic and hypothyroid women . Thyroid . 1998;8:1081–1086
  29. Ozata M , Ozısık G , Bıngol N , et al.   The effects of thyroid status on plasma leptin levels in women . J Endocrinol Invest . 1998;21:337–341
  30. Sreenan S , Caro JF , Refetoff S . Thyroid dysfunction is not associated with alterations in serum leptin level . Thyroid . 1997;7:407–409
  31. Mantzoros CS , Rosen HN , Greenspan SL , et al.   Short-term hyperthyroidism has no effect on leptin levels in man . J Clin Endocrinol Metab . 1997;82:497–499
  32. Syed MA , Thompson MP , Pachuckı J , et al.   The effect of thyroid hormone on size of fat depots accounts for most of the changes in leptin mRNA and serum levels in the rat . Thyroid . 1999;9:503–512
  33. Cusin I , Sainsbury A , Doyle P , et al.   The ob gene and insulin. A relationship leading to clues to the understanding of obesity . Diabetes . 1995;44:1467–1470
  34. Leroy P , Dessolin S , Villageois P , et al.   Expression of ob gene in adipose cells. Regulation by insulin . J Biol Chem . 1996;271:2365–2368
  35. De Vos P , Saladin R , Auwerx J , et al.   Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake . J Biol Chem . 1995;270:15958–15961
  36. Dagogo-Jack S , Selke G , Melson AK , et al.   Robust leptin secretory responses to dexamethasone in obese subjects . J Clin Endocrinol Metab . 1997;82:3230–3233
  37. Machinal-Quelin F , Dieudonne MN , Pecquery R , et al.   Direct in vitro effects of androgens and estrogens on ob gene expression and leptin secretion in human adipose tissue . Endocrine . 2002;18:179–184
  38. Fain JN , Leffler CW , Bahouth SW . Eicosanoids as endogenous regulators of leptin release and lipolysis by mouse adipose tissue in primary culture . J Lipid Res . 2000;41:1689–1694
  39. Garofalo C , Surmacz E . Leptin and cancer . J Cell Physiol . 2006;207:12–22
  40. Grosfeld A , Andre J , Hauguel-De Mouzon S , et al.   Hypoxiainducible factor 1 transactivates the human leptin gene promoter . J Biol Chem . 2002;277:42953–42957
  41. Ambrosini G , Nath AK , Sierra-Honigmann MR , et al.   Transcriptional activation of the human leptin gene in response to hypoxia. Involvement of hypoxia-inducible factor 1 . J Biol Chem . 2002;277:34601–34609
  42. Stenmark KR , Gerasimovskaya E , Nemenoff RA , et al.   Hypoxic activation of adventitial fibroblasts: role in vascular remodelling . Chest . 2002;122(6 Suppl):326S–334S
  43. Bouloumie A , Drexler HC , Lafontan M , et al.   Leptin, the product of Ob gene, promotes angiogenesis . Circ Res . 1998;83:1059–1066
  44. Cao R , Brakenhielm E , Wahlestedt C , et al.   Leptin induces vascular permeability and synergistically stimulates angiogenesis with FGF–2 and VEGF . Proc Natl Acad Sci USA . 2001;98:6390–6395
  45. Artwohl M , Roden M , Holzenbein T , et al.   Modulation by leptin of proliferation and apoptosis in vascular endothelial cells . Int J Obes Relat Metab Disord . 2002;26:577–580
  46. Park HY , Kwon HM , Lim HJ , et al.   Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro . Exp Mol Med . 2001;33:95–102
  47. Kume K , Satomura K , Nishisho S , et al.   Potential role of leptin in endochondral ossification . J Histochem Cytochem . 2002;50:159–169
  48. O'Brien SN , Welter BH , Price TM . Presence of leptin in breast cell lines and breast tumours . Biochem Biophys Res Commun . 1999;259:695–698
  49. Hardwick JC , Van Den Brink GR , Offerhaus GJ , et al.   Leptin is a growth factor for colonic epithelial cells . Gastroenterology . 2001;121:79–90
  50. Liu Z , Uesaka T , Watanabe H , et al.   High fat diet enhances colonic cell proliferation and carcinogenesis in rats by elevating serum leptin . Int J Oncol . 2001;19:1009–1014
  51. Dieudonne MN , Machinal-Quelin F , Serazin-Leroy V , et al.   Leptin mediates a proliferative response in human MCF7 breast cancer cells . Biochem Biophys Res Commun . 2002;293:622–628
  52. Laud K , Gourdou I , Pessemesse L , et al.   Identification of leptin receptors in human breast cancer: functional activity in the T47-D breast cancer cell line . Mol Cell Endocrinol . 2002;188:219–226
  53. Botella-Carretero JI , Alvarez-Blasco F , Sancho J , et al.   Effects of thyroid hormones on serum levels of adipokines as studied in patients with differentiated thyroid carcinoma during thyroxine withdrawal . Thyroid . 2006;16:397–402
  54. Considine RV , Sinha MK , Heiman ML , et al.   Serum immunoreactive-leptin concentrations in normal-weight and obese humans . N Engl J Med . 1996;334:292–295
  55. Brauner R , Trivin C , Zerah M , et al.   Diencephalic syndrome due to hypothalamic tumour: a model of the relationship between weight and puberty onset . J Clin Endocrinol Metab . 2006;91:2467–2473

PII: S1015-9584(09)60397-3

doi:10.1016/S1015-9584(09)60397-3

Asian Journal of Surgery
Volume 32, Issue 4 , Pages 216-223, October 2009

Article Tools