Xenoderm Versus 1% Silver Sulfadiazine in Partial-thickness Burns
Accepted 23 July 2009.
Objective
The aim of this clinical trial was to evaluate the effectiveness of using lyophilised porcine skin (Xenoderm) compared with 1% silver sulfadiazine (SSD) in partial-thickness burns with regard to wound infection, length of hospital stay, number of dressings and doses of analgesics used (oral and injection).
Methods
A total of 78 burns patients were included in this randomised study; their burns were caused by scalds or flames. They had second degree burns and had a burn area of 10-60% of total body surface area (TBSA). Thirty-seven patients were treated with daily washing, followed by topical application of SSD dressing (the SSD group) and 39 with a biological dressing, i.e. Xenoderm (the Xenoderm group). The differences were evaluated using unpaired Student's t-test, Mann-Whitney U test and Chi-square test.
Results
There were no significant differences between the two groups with respect to age, gender, TBSA, cause of burn, and thickness of the burn or burn site. But there were significant differences regarding degree of wound infection, length of hospital stay, number of used dressings and given doses of analgesics.
Conclusion
Xenoderm seems to be more effective than SSD dressing in terms of pain control, degree of wound infection, used wound dressings and length of hospital stay for partial-thickness burns. Prospective randomised studies are now necessary to compare possible reductions in the use of split thickness skin grafts and re-epithelialisation times.
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aBurns Department, Ayatollah-Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran
bSocial Medicine Department, School of Medicine, Zanjan, Iran
cSurgery Department, Ayatollah-Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran
dFaculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
eEmergency Department, Ayatollah-Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran
Address correspondence and reprint requests to Dr Seyed Nejat Hosseini, Assistant Professor, Faculty of Medicine, Zanjan University of Medical Sciences, Shahrak-Karmandan Street, Zanjan, Iran
ABSTRACT