Asian Journal of Surgery
Volume 32, Issue 4 , Pages 234-239, October 2009

Xenoderm Versus 1% Silver Sulfadiazine in Partial-thickness Burns

  • Seyed Nejat Hosseini

      Affiliations

    • Burns Department, Ayatollah-Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran
    • Corresponding Author InformationAddress correspondence and reprint requests to Dr Seyed Nejat Hosseini, Assistant Professor, Faculty of Medicine, Zanjan University of Medical Sciences, Shahrak-Karmandan Street, Zanjan, Iran
    • ,
  • Anayatollah Karimian

      Affiliations

    • Burns Department, Ayatollah-Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran
    • ,
  • Seyed Nouraddin Mousavinasab

      Affiliations

    • Social Medicine Department, School of Medicine, Zanjan, Iran
    • ,
  • Haleh Rahmanpour

      Affiliations

    • Surgery Department, Ayatollah-Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran
    • ,
  • Mehdi Yamini

      Affiliations

    • Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
    • ,
  • Shokoufeh Hosseini Zahmatkesh

      Affiliations

    • Emergency Department, Ayatollah-Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran

Accepted 23 July 2009.

Article Outline

Objective

The aim of this clinical trial was to evaluate the effectiveness of using lyophilised porcine skin (Xenoderm) compared with 1% silver sulfadiazine (SSD) in partial-thickness burns with regard to wound infection, length of hospital stay, number of dressings and doses of analgesics used (oral and injection).

Methods

A total of 78 burns patients were included in this randomised study; their burns were caused by scalds or flames. They had second degree burns and had a burn area of 10-60% of total body surface area (TBSA). Thirty-seven patients were treated with daily washing, followed by topical application of SSD dressing (the SSD group) and 39 with a biological dressing, i.e. Xenoderm (the Xenoderm group). The differences were evaluated using unpaired Student's t-test, Mann-Whitney U test and Chi-square test.

Results

There were no significant differences between the two groups with respect to age, gender, TBSA, cause of burn, and thickness of the burn or burn site. But there were significant differences regarding degree of wound infection, length of hospital stay, number of used dressings and given doses of analgesics.

Conclusion

Xenoderm seems to be more effective than SSD dressing in terms of pain control, degree of wound infection, used wound dressings and length of hospital stay for partial-thickness burns. Prospective randomised studies are now necessary to compare possible reductions in the use of split thickness skin grafts and re-epithelialisation times.

Key Words:  biological dressing , partial-thickness burns , silver sulfadiazine , Xenoderm

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PII: S1015-9584(09)60400-0

doi:10.1016/S1015-9584(09)60400-0

Asian Journal of Surgery
Volume 32, Issue 4 , Pages 234-239, October 2009

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