Volume 33, Issue 1, Pages 25-30 (January 2010)

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ABSTRACT

ABSTRACT + REFS

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Anti-adhesive Effect and Safety of Sodium Hyaluronate and Sodium Carboxymethyl Cellulose Solution in Thyroid Surgery

Accepted 17 March 2010.

Objective

A number of researchers have suggested the use of sodium hyaluronate carboxymethyl cellulose (HA-CMC) membrane for preventing postoperative adhesion. This study evaluated the anti-adhesive effect and safety of a newly developed HA-CMC solution in thyroidectomy.

Methods

Seventy-four patients who underwent thyroidectomy were prospectively randomized. In the study group of 38 patients, 5 mL HA-CMC solution was applied to the operative field after thyroidectomy. The subjects were asked about adhesive symptoms using a four-item questionnaire at 2 weeks, 2 months and 6 months after surgery. In addition, three items on the appearance of neck wrinkles and scars were evaluated by a physician. Each item was scored from 0 to 10.

Results

The mean (± standard deviation) total adhesion score at each visit was 15.22 ± 8.99, 10.42 ± 8.41, and 7.24 ± 5.83 for the control group and 19.29 ± 9.71, 9.46 ± 5.71, and 6.03 ± 4.32 for the study group. Total adhesion scores for both groups decreased with time (p < 0.001), but no significant differences were noted between the two groups (p > 0.066). There were no complications related to the HA-CMC solution.

Conclusion

The HA-CMC solution did not decrease subjective or objective postoperative adhesion in patients undergoing thyroid surgery, although it was biologically safe.

Key Words: anti-adhesive agents , postoperative adhesion , sodium hyaluronate carboxymethyl cellulose , thyroidectomy

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Article Outline

• Abstract

• References

• Copyright

References

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a Department of Surgery, St. Vincent's Hospital, The Catholic University of Korea, Gyeonggi-do, Seoul, Korea

b Department of Surgery, Seoul National University College of Medicine, Seoul, Korea

c Department of Surgery, Korea University College of Medicine, Seoul, Korea

d Department of Surgery, Sungkyunkwan University School of Medicine, Seoul, Korea

e Department of Surgery, Seoul National University Cancer Research Institute, Seoul, Korea

Department of Surgery, Kyung Hee University School of Medicine, Seoul, Korea

Address correspondence and reprint requests to Dr Yeo-Kyu Youn, Department of Surgery, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Korea

PII: S1015-9584(10)60005-X

doi:10.1016/S1015-9584(10)60005-X

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