Volume 33, Issue 1, Pages 42-50 (January 2010)

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ABSTRACT

ABSTRACT + REFS

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Role of High Augmentation Index in Spontaneous Intracerebral Haemorrhage

Accepted 17 March 2010.

Background

Intracerebral haemorrhage (ICH) is the most disabling and least treatable form of stroke. Its risk factors include old age, hypertension, diabetes mellitus, hypercholesterolaemia, smoking and high alcohol intake, which are also associated with arterial stiffness. The aim of the present study was to determine the prognostic value of high augmentation index (AI), which is a surrogate marker of arterial stiffness, in patients with spontaneous ICH.

Methods

A prospective study of 60 patients with spontaneous supratentorial ICH was conducted. Outcome was assessed using the Modified Rankin Scale at 3 months follow-up. Data were collected on age and sex, risk factors for ICH, clinical parameters, laboratory parameters, radiological findings and hospital management. Logistic regression analysis was carried out to identify independent predictors of 3-month outcome and mortality.

Results

Admission Glasgow Coma Scale score (OR, 0.7; 95% CI, 0.450–0.971; p = 0.035), total leukocyte count (OR,1.2; 95% CI, 1.028–1.453; p = 0.023) and haematoma volume (OR, 1.1; 95% CI, 1.024–1.204; p = 0.011) were found to be statistically significant in multivariate analysis of 3-month poor outcome. Factors independently associated with mortality were high AI (OR, 8.6; 95%CI, 1.748–40.940; p = 0.007) and midline shift (OR, 7.5; 95%CI, 1.809–31.004; p = 0.005).

Conclusion

Admission Glasgow Coma Scale score, total leukocyte count and haematoma volume were significant predictors for 3-month poor outcome; high AI and midline shift were significant predictors for 3-month mortality.

Key Words: augmentation index , Glasgow Coma Scale , intracerebral haemorrhage , mortality , prognosis , triglyceride

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Article Outline

• Abstract

• References

• Copyright

References

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Department of Neuroscience, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia

Address correspondence and reprint requests to Dr Hock Keong Lee, Department of Neuroscience, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia

PII: S1015-9584(10)60008-5

doi:10.1016/S1015-9584(10)60008-5

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